Protein-coding gene in the species Homo sapiens
| IWS1 |
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| Identifiers |
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| Aliases | IWS1, SUPT6H interacting protein, interacts with SUPT6H, CTD assembly factor 1 |
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| External IDs | MGI: 1920723; HomoloGene: 134421; GeneCards: IWS1; OMA:IWS1 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 2 (human)[1] |
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| | Band | 2q14.3 | Start | 127,436,207 bp[1] |
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| End | 127,526,886 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 18 (mouse)[2] |
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| | Band | 18|18 B1 | Start | 32,200,794 bp[2] |
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| End | 32,237,381 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - tibialis anterior muscle
- mucosa of ileum
- Achilles tendon
- tendon of biceps brachii
- gastrocnemius muscle
- gonad
- right auricle
- sural nerve
- left ventricle
- apex of heart
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| | Top expressed in | - tail of embryo
- hand
- otolith organ
- utricle
- genital tubercle
- superior cervical ganglion
- zygote
- trigeminal ganglion
- spermatocyte
- spermatid
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| | More reference expression data |
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| BioGPS | 
 | | More reference expression data |
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| Gene ontology |
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| Molecular function | | | Cellular component | | | Biological process | - regulation of transcription, DNA-templated
- mRNA transport
- RNA splicing
- regulation of histone H4 acetylation
- regulation of mRNA processing
- mRNA processing
- regulation of mRNA export from nucleus
- regulation of histone H3-K36 trimethylation
- transcription, DNA-templated
- transcription by RNA polymerase II
- transcription elongation from RNA polymerase II promoter
- regulation of DNA-templated transcription, elongation
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 2: 127.44 – 127.53 Mb | Chr 18: 32.2 – 32.24 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Protein IWS1 homolog also known as interacts with Spt6 (IWS1) is a protein that in humans is encoded by the IWS1 gene.[5]
IWS1 is a transcription elongation factor. It was first identified during a search for RNA polymerase II-associated elongation factors in yeast; it directly interacts with RNA polymerase II (RNAPII) and is phosphorylated at casein kinase II (CKII) sites.[6]
The human homolog, which physically interacts with protein arginine methyltransferase 5 (PRMT5), is essential for cell survival.[7] It also recruits a SET2 histone methyltransferase (Huntingtin-interacting protein HYPB, also known as SETD2) to RNAPII during transcription elongation and is required for H3K36 trimethylation.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163166 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024384 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: IWS1 IWS1 homolog (S. cerevisiae)".
- ^ Krogan NJ, Kim M, Ahn SH, Zhong G, Kobor MS, Cagney G, Emili A, Shilatifard A, Buratowski S, Greenblatt JF (Oct 2002). "RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach". Molecular and Cellular Biology. 22 (20): 6979–92. doi:10.1128/MCB.22.20.6979-6992.2002. PMC 139818. PMID 12242279.
- ^ Liu Z, Zhou Z, Chen G, Bao S (Feb 2007). "A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation". Biochemical and Biophysical Research Communications. 353 (1): 47–53. doi:10.1016/j.bbrc.2006.11.133. PMID 17184735.
- ^ Yoh SM, Lucas JS, Jones KA (Dec 2008). "The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation". Genes & Development. 22 (24): 3422–34. doi:10.1101/gad.1720008. PMC 2607075. PMID 19141475.
Further reading
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Ling Y, Smith AJ, Morgan GT (2006). "A sequence motif conserved in diverse nuclear proteins identifies a protein interaction domain utilised for nuclear targeting by human TFIIS". Nucleic Acids Research. 34 (8): 2219–29. doi:10.1093/nar/gkl239. PMC 1450333. PMID 16648364.
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Liu Z, Zhou Z, Chen G, Bao S (Feb 2007). "A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation". Biochemical and Biophysical Research Communications. 353 (1): 47–53. doi:10.1016/j.bbrc.2006.11.133. PMID 17184735.
- Yoh SM, Cho H, Pickle L, Evans RM, Jones KA (Jan 2007). "The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export". Genes & Development. 21 (2): 160–74. doi:10.1101/gad.1503107. PMC 1770899. PMID 17234882.
