Katehol O-metiltransferaza
| Katehol O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.1.1.6 | ||||||||
| CAS broj | 9012-25-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Katehol O-metiltransferaza (EC 2.1.1.6, COMT I, COMT II, S-COMT, rastvorna forma katehol-O-metiltransferaze, MB-COMT, membranska forma katehol-O-metiltransferaze, kateholna metiltransferaza, kateholaminska O-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:katehol O-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + katehol S-adenozil-L-homocistein + gvajakol
Enzim sisara deluje brže na kateholamine kao što je adrenalin ili noradrenalin nego na katehole.
Reference
- ^ Axelrod, J. & Tomchick, R. (1958). „Enzymatic O-methylation of epinephrine and other catechols”. J. Biol. Chem. 233: 702—705. PMID 13575440.
- ^ Gulliver, P.A. & Tipton, K.F. (1979). „The purification and properties of pig brain catechol-O-methyltransferase”. J. Neurochem. 32: 1525—1529. PMID 438821.
- ^ Huh, M.M.O. & Friedhof, A.J. (1979). „Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization”. J. Biol. Chem. 254: 299—308. PMID 762061.
Literatura
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
- Catechol+O-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
- п
- р
- у
Transferaze: jednougljenične transferaze (EC 2.1)
| N- | |
|---|---|
| O- |
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| Homocistein | |
| Drugi |
formil- i srodne grupe
| Hidroksimetiltransferaza | |
|---|---|
| Formiltransferaza | |
| Drugi |
i karbamoil
| Karboksi | |
|---|---|
| Karbamoil |
- Arginin:glicin amidinotransferaza
Portali:
Molekularna i ćelijska biologija
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