SEPT10

Protein-coding gene in the species Homo sapiens
SEPTIN10
Identifiers
AliasesSEPTIN10, septin 10, SEPT10
External IDsOMIM: 611737; MGI: 1918110; HomoloGene: 27035; GeneCards: SEPTIN10; OMA:SEPTIN10 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SEPTIN10
Genomic location for SEPTIN10
Band2q13Start109,542,799 bp[1]
End109,614,143 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SEPTIN10
Genomic location for SEPTIN10
Band10|10 B4Start59,141,627 bp[2]
End59,221,847 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of hip

  • skin of thigh

  • oral cavity

  • skin of arm

  • germinal epithelium

  • human penis

  • Epithelium of choroid plexus

  • hair follicle

  • amniotic fluid

  • parietal pleura
Top expressed in
  • spermatocyte

  • spermatid

  • atrioventricular valve

  • endocardial cushion

  • seminiferous tubule

  • genital tubercle

  • corneal stroma

  • cardiac muscle tissue of left ventricle

  • ventricular zone

  • tail of embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • protein binding
  • GTPase activity
  • molecular adaptor activity
Cellular component
  • cytoplasm
  • cytoskeleton
  • septin ring
  • microtubule cytoskeleton
  • septin complex
  • septin filament array
Biological process
  • cell cycle
  • cell division
  • mitotic cytokinesis
  • septin ring assembly
  • cilium assembly
  • cytoskeleton-dependent cytokinesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

151011

103080

Ensembl

ENSG00000186522

ENSMUSG00000019917

UniProt

Q9P0V9

Q8C650

RefSeq (mRNA)
NM_144710
NM_178584
NM_001321496
NM_001321498
NM_001321499

NM_001321500
NM_001321501
NM_001321502
NM_001321503
NM_001321504
NM_001321505
NM_001321506
NM_001321507
NM_001321508
NM_001321509
NM_001321510
NM_001321511
NM_001321512
NM_001321513
NM_001321514
NM_001321515

NM_001024910
NM_001024911

RefSeq (protein)
NP_001308425
NP_001308427
NP_001308428
NP_001308429
NP_001308430

NP_001308431
NP_001308432
NP_001308433
NP_001308434
NP_001308435
NP_001308436
NP_001308437
NP_001308438
NP_001308439
NP_001308440
NP_001308441
NP_001308442
NP_001308443
NP_001308444
NP_653311
NP_848699
NP_001308427.1

NP_001020081
NP_001020082
NP_001365992
NP_001365993
NP_001365994

NP_001365995

Location (UCSC)Chr 2: 109.54 – 109.61 MbChr 10: 59.14 – 59.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Septin 10 is a protein that in humans is encoded by the SEPT10 gene.[5]

Function

This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternative splicing results in multiple transcript variants.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186522 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019917 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Septin 10".

Further reading

  • Sui L, Zhang W, Liu Q, Chen T, Li N, Wan T, Yu M, Cao X (May 2003). "Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells". Biochemical and Biophysical Research Communications. 304 (2): 393–8. doi:10.1016/s0006-291x(03)00601-6. PMID 12711328.
  • Benedetti D, Bomben R, Dal-Bo M, Marconi D, Zucchetto A, Degan M, Forconi F, Del-Poeta G, Gaidano G, Gattei V (January 2008). "Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10". Leukemia. 22 (1): 224–6. doi:10.1038/sj.leu.2404867. PMID 17657217.
  • Xu M, Takanashi M, Oikawa K, Nishi H, Isaka K, Yoshimoto T, Ohyashiki J, Kuroda M (April 2012). "Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen". Cancer Science. 103 (4): 821–7. doi:10.1111/j.1349-7006.2012.02221.x. PMC 7659246. PMID 22320903. S2CID 3456503.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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