SEMA4C

Protein-coding gene in the species Homo sapiens
SEMA4C
Identifiers
AliasesSEMA4C, M-SEMA-F, SEMACL1, SEMAF, SEMAI, semaphorin 4C
External IDsOMIM: 604462; MGI: 109252; HomoloGene: 23047; GeneCards: SEMA4C; OMA:SEMA4C - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SEMA4C
Genomic location for SEMA4C
Band2q11.2Start96,859,718 bp[1]
End96,870,757 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for SEMA4C
Genomic location for SEMA4C
Band1|1 BStart36,587,720 bp[2]
End36,597,430 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • olfactory bulb

  • trigeminal ganglion

  • spinal ganglia

  • cerebellar vermis

  • tibial nerve

  • inferior ganglion of vagus nerve

  • sural nerve

  • inferior olivary nucleus

  • endothelial cell

  • pericardium
Top expressed in
  • sciatic nerve

  • trigeminal ganglion

  • aortic valve

  • Rostral migratory stream

  • otolith organ

  • utricle

  • ascending aorta

  • ganglionic eminence

  • tail of embryo

  • decidua
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • neuropilin binding
  • semaphorin receptor binding
  • chemorepellent activity
Cellular component
  • integral component of membrane
  • postsynaptic membrane
  • postsynaptic density
  • plasma membrane
  • synapse
  • synaptic vesicle membrane
  • cell junction
  • cytoplasmic vesicle
  • extracellular space
  • membrane
  • integral component of plasma membrane
Biological process
  • cell differentiation
  • cell migration in hindbrain
  • cerebellum development
  • nervous system development
  • multicellular organism development
  • muscle cell differentiation
  • neural tube closure
  • positive regulation of stress-activated MAPK cascade
  • semaphorin-plexin signaling pathway
  • negative chemotaxis
  • neural crest cell migration
  • positive regulation of cell migration
  • negative regulation of axon extension involved in axon guidance
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54910

20353

Ensembl

ENSG00000168758

ENSMUSG00000026121

UniProt

Q9C0C4

Q64151

RefSeq (mRNA)

NM_017789

NM_001126047
NM_001304329
NM_001304330

RefSeq (protein)

NP_060259

NP_001119519
NP_001291258
NP_001291259

Location (UCSC)Chr 2: 96.86 – 96.87 MbChr 1: 36.59 – 36.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Semaphorin-4C is a protein that in humans is encoded by the SEMA4C gene.[5][6]

Interactions

SEMA4C has been shown to interact with DLG4.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168758 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026121 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Inagaki S, Furuyama T, Iwahashi Y (October 1995). "Identification of a member of mouse semaphorin family". FEBS Lett. 370 (3): 269–72. doi:10.1016/0014-5793(95)00850-9. PMID 7656991.
  6. ^ "Entrez Gene: SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C".
  7. ^ Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (March 2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.

Further reading

  • Simmons AD, Püschel AW, McPherson JD, Overhauser J, Lovett M (1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem. Biophys. Res. Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
  • Wang LH, Kalb RG, Strittmatter SM (1999). "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF". J. Biol. Chem. 274 (20): 14137–46. doi:10.1074/jbc.274.20.14137. PMID 10318831.
  • Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.
  • Ohoka Y, Hirotani M, Sugimoto H, Fujioka S, Furuyama T, Inagaki S (2001). "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75". Biochem. Biophys. Res. Commun. 280 (1): 237–43. doi:10.1006/bbrc.2000.4080. PMID 11162505.
  • Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.


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