Perfluorohexyloctane
- US DailyMed: Perfluorohexyloctane
administration
- None
- US: ℞-only[1]
- 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorotetradecane
- 133331-77-8
- 10477896
- DB17823
- 8653305
- 7VYX4ELWQM
- D12604
- CHEBI:229658
- DTXSID20440585
- Interactive image
- CCCCCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
- InChI=1S/C14H17F13/c1-2-3-4-5-6-7-8-9(15,16)10(17,18)11(19,20)12(21,22)13(23,24)14(25,26)27/h2-8H2,1H3
- Key:WRYIIOKOQSICTB-UHFFFAOYSA-N
Perfluorohexyloctane, sold under the brand names EvoTears[2] (Europe), NovaTears[3] (Australia, New Zealand), and Miebo[4] (USA), is a medication used for the treatment of dry eye disease.[1] It is a semifluorinated alkane.[1]
Perfluorohexyloctane has been available in multiple markets since 2015 under the brand names EvoTears and NovaTears,[5] and was additionally approved for medical use in the United States in May 2023 under the brand Miebo.[1][6] The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.[7]
Perfluorohexyloctane when sold under the brand names EvoTears or NovaTears is available in multiple countries over-the-counter[8] costing NZ$34.00,[9] AUD: $30,[10] €30[11] for approximately a one-month supply. When sold in the USA under the brand Miebo a prescription is required.
Medical uses
Perfluorohexyloctane is indicated for the treatment of the signs and symptoms of dry eye disease.[1][12][13]
References
- ^ a b c d e "Miebo- perfluorohexyloctane solution". DailyMed. 18 May 2023. Retrieved 8 June 2023.
- ^ "EvoTears - Official Website". Retrieved 15 February 2024.
- ^ "NovaTears - AFT Pharmaceuticals". Retrieved 15 February 2024.
- ^ "MIEBO (perfluorohexyloctane ophthalmic solution) | RX Dry Eye Drops". www.miebo.com. Retrieved 5 June 2024.
- ^ "URSAPHARM GmbH and Novaliq GmbH Announce European Partnership Agreement". Retrieved 15 February 2024.
- ^ "Bausch + Lomb and Novaliq Announce FDA Approval of Miebo (Perfluorohexyloctane Ophthalmic Solution) for the Treatment of the Signs and Symptoms of Dry Eye Disease" (Press release). Bausch + Lomb Corporation. 18 May 2023. Retrieved 8 June 2023 – via Business Wire.
- ^ New Drug Therapy Approvals 2023 (PDF). U.S. Food and Drug Administration (FDA) (Report). January 2024. Archived from the original on 10 January 2024. Retrieved 9 January 2024.
- ^ "Global Availability Announcement". Retrieved 15 February 2024.
- ^ "Novatears 3ml - Life Pharmacy New Zealand". Retrieved 15 February 2024.
- ^ "NovaTears Preservative Free Lubricating Eye Drops 3ml - Chemist Warehouse Australia". Retrieved 15 February 2024.
- ^ "Evotears Eye Drops 3ml - Amazon.de". Retrieved 15 February 2024.
- ^ Ballesteros-Sánchez A, De-Hita-Cantalejo C, Sánchez-González MC, Jansone-Langine Z, de Sotomayor MA, Culig J, et al. (October 2023). "Perfluorohexyloctane in dry eye disease: A systematic review of its efficacy and safety as a novel therapeutic agent". The Ocular Surface. 30: 254–262. doi:10.1016/j.jtos.2023.10.001. hdl:11441/151762. PMID 37813152. S2CID 263802332.
- ^ Sheppard JD, Evans DG, Protzko EE (November 2023). "A review of the first anti-evaporative prescription treatment for dry eye disease: perfluorohexyloctane ophthalmic solution". The American Journal of Managed Care. 29 (14 Suppl): S251–S259. doi:10.37765/ajmc.2023.89464. PMID 37930231. S2CID 265032840.