PSMA8

Protein found in humans

PSMA8

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4R3O, 4R67

Identifiers

Aliases

PSMA8, PSMA7L, proteasome subunit alpha 8, proteasome 20S subunit alpha 8

External IDs

OMIM: 617841; MGI: 1920927; HomoloGene: 2086; GeneCards: PSMA8; OMA:PSMA8 - orthologs

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	18q11.2	Start	26,133,852 bp^[1]
Band	18q11.2	End	26,193,355 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 A1	Start	14,839,208 bp^[2]
Band	18\|18 A1	End	14,895,358 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right testis

sperm

left testis

testicle

buccal mucosa cell

gonad

lymph node

granulocyte

appendix

pharynx

Top expressed in

spermatocyte

spermatid

seminiferous tubule

blastocyst

embryo

embryo

endocardial cushion

atrioventricular valve

morula

Gonadal ridge

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	endopeptidase activity peptidase activity threonine-type endopeptidase activity hydrolase activity
Cellular component	cytoplasm cytosol spermatoproteasome complex proteasome complex extracellular exosome nucleus proteasome core complex proteasome core complex, alpha-subunit complex
Biological process	regulation of cellular amino acid metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of mRNA stability ubiquitin-dependent protein catabolic process positive regulation of canonical Wnt signaling pathway protein polyubiquitination stimulatory C-type lectin receptor signaling pathway tumor necrosis factor-mediated signaling pathway MAPK cascade proteolysis Fc-epsilon receptor signaling pathway NIK/NF-kappaB signaling anaphase-promoting complex-dependent catabolic process proteolysis involved in cellular protein catabolic process T cell receptor signaling pathway negative regulation of canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia post-translational protein modification regulation of hematopoietic stem cell differentiation proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


143471


73677

Ensembl


ENSG00000154611


ENSMUSG00000036743

UniProt


Q8TAA3


Q9CWH6

RefSeq (mRNA)


NM_001025096 NM_001025097 NM_001308188 NM_144662


NM_001163609 NM_001360823

RefSeq (protein)


NP_001020267 NP_001020268 NP_001295117 NP_653263


NP_001157081 NP_001347752

Location (UCSC)

Chr 18: 26.13 – 26.19 Mb

Chr 18: 14.84 – 14.9 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Proteasome subunit alpha 8 also known as proteasome subunit alpha type-7-like is a protein that in humans is encoded by the PSMA8 gene.^[5] Proteasome subunit alpha 8 is a component of the sperm specific proteasome.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154611 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036743 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PSMA8 proteasome subunit alpha 8".
^ de Mateo S, Castillo J, Estanyol JM, Ballescà JL, Oliva R (2011). "Proteomic characterization of the human sperm nucleus". Proteomics. 11 (13): 2714–26. doi:10.1002/pmic.201000799. PMID 21630459. S2CID 9305926.