NRBP1

Protein-coding gene in the species Homo sapiens
NRBP1
Identifiers
AliasesNRBP1, BCON3, MADM, MUDPNP, NRBP, nuclear receptor binding protein 1
External IDsOMIM: 606010; MGI: 2183436; HomoloGene: 8373; GeneCards: NRBP1; OMA:NRBP1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for NRBP1
Genomic location for NRBP1
Band2p23.3Start27,427,790 bp[1]
End27,442,259 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for NRBP1
Genomic location for NRBP1
Band5|5 B1Start31,398,208 bp[2]
End31,408,910 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • gastric mucosa

  • left testis

  • body of uterus

  • ectocervix

  • canal of the cervix

  • stromal cell of endometrium

  • granulocyte

  • muscle layer of sigmoid colon

  • right ovary
Top expressed in
  • tail of embryo

  • genital tubercle

  • neural layer of retina

  • granulocyte

  • ventricular zone

  • dentate gyrus of hippocampal formation granule cell

  • lip

  • muscle of thigh

  • primary visual cortex

  • superior frontal gyrus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein kinase activity
  • protein binding
  • ATP binding
  • protein serine/threonine kinase activity
  • protein homodimerization activity
Cellular component
  • cytoplasm
  • cell projection
  • cell cortex
  • membrane
  • endomembrane system
  • lamellipodium
  • nucleoplasm
  • cytosol
Biological process
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • transcription initiation from RNA polymerase II promoter
  • intracellular signal transduction
  • protein phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29959

192292

Ensembl

ENSG00000115216

ENSMUSG00000029148

UniProt

Q9UHY1

Q99J45

RefSeq (mRNA)
NM_013392
NM_001321357
NM_001321358
NM_001321359
NM_001321361

NM_001321362
NM_001321363

NM_147201
NM_001347326

RefSeq (protein)
NP_001308286
NP_001308287
NP_001308288
NP_001308290
NP_001308291

NP_001308292
NP_037524

NP_001334255
NP_671734

Location (UCSC)Chr 2: 27.43 – 27.44 MbChr 5: 31.4 – 31.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear receptor-binding protein is a protein that in humans is encoded by the NRBP1 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115216 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029148 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hooper JD, Baker E, Ogbourne SM, Sutherland GR, Antalis TM (Jul 2000). "Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein". Genomics. 66 (1): 113–8. doi:10.1006/geno.2000.6167. PMID 10843813.
  6. ^ De Langhe S, Haataja L, Senadheera D, Groffen J, Heisterkamp N (Apr 2002). "Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". Int J Mol Med. 9 (5): 451–9. doi:10.3892/ijmm.9.5.451. PMID 11956649.
  7. ^ "Entrez Gene: NRBP1 nuclear receptor binding protein 1".

Further reading

  • Martinez P (1976). "[A nurse with the drug addicts]". Revue de l'Infirmière. 26 (7): 557–62. PMID 1048605.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Lim R, Winteringham LN, Williams JH, et al. (2002). "MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1". J. Biol. Chem. 277 (43): 40997–1008. doi:10.1074/jbc.M206041200. PMID 12176995.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Chua JJ, Ng MM, Chow VT (2004). "The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure". Virus Res. 102 (2): 151–63. doi:10.1016/j.virusres.2004.01.025. PMID 15084397.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Wang H, Sun X, Luo Y, et al. (2006). "Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity". FEBS Lett. 580 (25): 6015–21. doi:10.1016/j.febslet.2006.10.002. PMID 17052710. S2CID 2427625.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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