N-acetylhexosamine 1-dehydrogenase

In enzymology, a N-acetylhexosamine 1-dehydrogenase (EC 1.1.1.240) is an enzyme that catalyzes the chemical reaction

N-acetyl-D-glucosamine + NAD⁺ ${\displaystyle \rightleftharpoons }$ N-acetyl-D-glucosaminate + NADH + H⁺

Thus, the two substrates of this enzyme are N-acetyl-D-glucosamine and NAD⁺, whereas its 3 products are N-acetyl-D-glucosaminate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is N-acetyl-D-hexosamine:NAD⁺ 1-oxidoreductase. Other names in common use include N-acetylhexosamine dehydrogenase, and N-acetyl-D-hexosamine dehydrogenase.

References

• Horiuchi T, Kurokawa T (1989). "Purification and characterization of N-acetyl-D-hexosamine dehydrogenase from Pseudomonas sp no 53". Agric. Biol. Chem. 53 (7): 1919–1925. doi:10.1271/bbb1961.53.1919.