JAG2

Protein-coding gene in the species Homo sapiens

JAG2

Identifiers

Aliases

JAG2, HJ2, SER2, jagged 2, jagged canonical Notch ligand 2, LGMDR27

External IDs

OMIM: 602570; MGI: 1098270; HomoloGene: 1677; GeneCards: JAG2; OMA:JAG2 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q32.33	Start	105,140,982 bp^[1]
Band	14q32.33	End	105,168,824 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12 F1\|12 61.37 cM	Start	112,871,439 bp^[2]
Band	12 F1\|12 61.37 cM	End	112,893,396 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

nipple

apex of heart

pituitary gland

skin of abdomen

anterior pituitary

skin of leg

skin of thigh

endothelial cell

olfactory zone of nasal mucosa

right frontal lobe

Top expressed in

primary oocyte

molar

secondary oocyte

esophagus

superior frontal gyrus

corneal stroma

hair follicle

muscle of thigh

external carotid artery

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	calcium ion binding Notch binding protein binding growth factor activity
Cellular component	integral component of membrane membrane plasma membrane integral component of plasma membrane
Biological process	Notch signaling pathway skeletal system development respiratory system process epithelial cell apoptotic process involved in palatal shelf morphogenesis in utero embryonic development multicellular organism development odontogenesis of dentin-containing tooth cell communication auditory receptor cell fate commitment T cell differentiation regulation of cell adhesion spermatogenesis morphogenesis of embryonic epithelium gamma-delta T cell differentiation thymic T cell selection positive regulation of Notch signaling pathway cell differentiation regulation of cell population proliferation regulation of signaling receptor activity negative regulation of Notch signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3714


16450

Ensembl


ENSG00000184916


ENSMUSG00000002799

UniProt


Q9Y219


Q9QYE5

RefSeq (mRNA)


NM_002226 NM_145159


NM_010588

RefSeq (protein)


NP_002217 NP_660142


NP_034718

Location (UCSC)

Chr 14: 105.14 – 105.17 Mb

Chr 12: 112.87 – 112.89 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Jagged-2 is a protein that in humans is encoded by the JAG2 gene.^[5]^[6]^[7]

Function

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

JAG2 has been shown to interact with NOTCH2.^[8]

MicroRNA miR-1280 has been shown to inhibit JAG2 expression.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184916 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002799 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (October 1997). "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor". Mol Cell Biol. 17 (10): 6057–67. doi:10.1128/MCB.17.10.6057. PMC 232455. PMID 9315665.
^ Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (April 2000). "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene". Genomics. 63 (1): 133–8. doi:10.1006/geno.1999.6045. PMID 10662552.
^ ^a ^b "Entrez Gene: JAG2 jagged 2".
^ Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
^ Wang, Remke, Bhat, Wong, Zhou, Ramaswamy, Dubuc, Fonkem, Salem, Zhang, Hsieh, O'Rourke, Wu, Li, Hawkins, Kohane, Wu, Wu, Taylor (February 2015). "A MicroRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma". Oncotarget. 6 (5): 2709–24. doi:10.18632/oncotarget.2779. PMC 4413612. PMID 25576913.

Shawber C, Boulter J, Lindsell CE, Weinmaster G (1997). "Jagged2: a serrate-like gene expressed during rat embryogenesis". Dev. Biol. 180 (1): 370–6. doi:10.1006/dbio.1996.0310. PMID 8948600.
Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI (1998). "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions". Mech. Dev. 69 (1–2): 203–7. doi:10.1016/S0925-4773(97)00146-9. PMID 9486542. S2CID 15978116.
Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999). "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC 1866435. PMID 10079256.
Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T, Kelley MW (1999). "Notch signalling pathway mediates hair cell development in mammalian cochlea". Nat. Genet. 21 (3): 289–92. doi:10.1038/6804. PMID 10080181. S2CID 6801552.
Felli MP, Maroder M, Mitsiadis TA, Campese AF, Bellavia D, Vacca A, Mann RS, Frati L, Lendahl U, Gulino A, Screpanti I (1999). "Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development". Int. Immunol. 11 (7): 1017–25. doi:10.1093/intimm/11.7.1017. PMID 10383933.
Tsai S, Fero J, Bartelmez S (2000). "Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact". Blood. 96 (3): 950–7. doi:10.1182/blood.V96.3.950. PMID 10910909.
Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.
Cereseto A, Tsai S (2000). "Jagged2 induces cell cycling in confluent fibroblasts susceptible to density-dependent inhibition of cell division". J. Cell. Physiol. 185 (3): 425–31. doi:10.1002/1097-4652(200012)185:3<425::AID-JCP13>3.0.CO;2-U. PMID 11056013. S2CID 683811.
Lindner V, Booth C, Prudovsky I, Small D, Maciag T, Liaw L (2001). "Members of the Jagged/Notch Gene Families Are Expressed in Injured Arteries and Regulate Cell Phenotype via Alterations in Cell Matrix and Cell-Cell Interaction". Am. J. Pathol. 159 (3): 875–83. doi:10.1016/S0002-9440(10)61763-4. PMC 1850458. PMID 11549580.
Hayashi T, Kageyama Y, Ishizaka K, Xia G, Kihara K, Oshima H (2002). "Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes". J. Androl. 22 (6): 999–1011. doi:10.1002/j.1939-4640.2001.tb03441.x. PMID 11700865.
Ikeuchi T, Sisodia SS (2003). "The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage". J. Biol. Chem. 278 (10): 7751–4. doi:10.1074/jbc.C200711200. PMID 12551931.
Houde C, Li Y, Song L, Barton K, Zhang Q, Godwin J, Nand S, Toor A, Alkan S, Smadja NV, Avet-Loiseau H, Lima CS, Miele L, Coignet LJ (2004). "Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines". Blood. 104 (12): 3697–704. doi:10.1182/blood-2003-12-4114. PMID 15292061.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.