ERLEC1

Protein-coding gene in the species Homo sapiens
ERLEC1
Identifiers
AliasesERLEC1, C2orf30, CIM, CL24936, CL25084, HEL117, XTP3-B, XTP3TPB, endoplasmic reticulum lectin 1
External IDsOMIM: 611229; MGI: 1914003; HomoloGene: 9247; GeneCards: ERLEC1; OMA:ERLEC1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ERLEC1
Genomic location for ERLEC1
Band2p16.2Start53,787,009 bp[1]
End53,833,038 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for ERLEC1
Genomic location for ERLEC1
Band11|11 A4Start30,930,774 bp[2]
End30,954,335 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic epithelial cell

  • endothelial cell

  • mucosa of ileum

  • cardiac muscle tissue of right atrium

  • tibia

  • tibialis anterior muscle

  • pancreatic ductal cell

  • decidua

  • corpus epididymis

  • middle temporal gyrus
Top expressed in
  • seminal vesicula

  • Rostral migratory stream

  • Epithelium of choroid plexus

  • fossa

  • parotid gland

  • stroma of bone marrow

  • islet of Langerhans

  • supraoptic nucleus

  • retinal pigment epithelium

  • calvaria
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • unfolded protein binding
  • protein binding
Cellular component
  • endoplasmic reticulum lumen
  • endoplasmic reticulum quality control compartment
  • endoplasmic reticulum
Biological process
  • ERAD pathway
  • negative regulation of retrograde protein transport, ER to cytosol
  • transmembrane transport
  • ubiquitin-dependent ERAD pathway
  • retrograde protein transport, ER to cytosol
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27248

66753

Ensembl

ENSG00000068912

ENSMUSG00000020311

UniProt

Q96DZ1

Q8VEH8

RefSeq (mRNA)

NM_001127397
NM_001127398
NM_015701

NM_025745

RefSeq (protein)

NP_001120869
NP_001120870
NP_056516

NP_080021

Location (UCSC)Chr 2: 53.79 – 53.83 MbChr 11: 30.93 – 30.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Endoplasmic reticulum lectin 1 is a protein that in humans is encoded by the ERLEC1 gene.[5][6][7][8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000068912 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020311 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  6. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  7. ^ Cruciat CM, Hassler C, Niehrs C (2006). "The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition". J. Biol. Chem. 281 (18): 12986–93. doi:10.1074/jbc.M511872200. PMID 16531414.
  8. ^ Christianson JC, Shaler TA, Tyler RE, Kopito RR (2008). "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD". Nat. Cell Biol. 10 (3): 272–82. doi:10.1038/ncb1689. PMC 2757077. PMID 18264092.
  9. ^ "Entrez Gene: C2orf30 chromosome 2 open reading frame 30".

Further reading

  • Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.


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