4-PPBP
Names | |
---|---|
Preferred IUPAC name 4-Phenyl-1-(4-phenylbutyl)piperidine | |
Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
ChEMBL |
|
ChemSpider |
|
MeSH | 4-phenyl-1-(4-phenylbutyl)piperidine |
PubChem CID |
|
UNII |
|
CompTox Dashboard (EPA) |
|
InChI
| |
| |
Properties | |
Chemical formula | C21H27N |
Molar mass | 293.446 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
4-PPBP is a neuroprotective cyclic amine which binds to sigma receptors.[1]
4-PPBP decreases neuronal nitric oxide synthase (nNOS) activity and ischemia-evoked nitric oxide (NO) production. 4-PPBP provides neuroprotection; this involves the prevention of ischemia-induced intracellular Ca2+ dysregulation.[2] 4-PPBP protects neurons using a mechanism that activates the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB). Neuroprotection that is associated with 4-PPBP increases Bcl-2 expression; Bcl-2 expression is regulated by CREB.[3]
See also
References
- ^ Yang S, Bhardwaj A, Cheng J, Alkayed NJ, Hurn PD, Kirsch JR (May 2007). "Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2". Anesthesia and Analgesia. 104 (5): 1179–84, tables of contents. doi:10.1213/01.ane.0000260267.71185.73. PMC 2596726. PMID 17456670.
- ^ Yang ZJ, Carter EL, Torbey MT, Martin LJ, Koehler RC (January 2010). "Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons". Experimental Neurology. 221 (1): 166–74. doi:10.1016/j.expneurol.2009.10.019. PMC 2812675. PMID 19883643.
- ^ Yang S, Alkayed NJ, Hurn PD, Kirsch JR (March 2009). "Cyclic adenosine monophosphate response element-binding protein phosphorylation and neuroprotection by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP)". Anesthesia and Analgesia. 108 (3): 964–70. doi:10.1213/ane.0b013e318192442c. PMC 2828492. PMID 19224810.
- v
- t
- e
- Agonists: 3-PPP
- 4-PPBP
- 5-MeO-DMT
- Alazocine (SKF-10047)
- Amantadine
- Arketamine
- BD-737
- BD-1052
- Blarcamesine
- Captodiame
- Citalopram
- CGRPTooltip Calcitonin gene-related peptide
- Cloperastine
- Cocaine
- Cutamesine (SA-4503)
- Cyclazocine
- Dehydroepiandrosterone (DHEA) (prasterone)
- Dehydroepiandrosterone sulfate (DHEA-S) (prasterone sulfate)
- Dextrallorphan
- Dextromethorphan (DXM)
- Dextrorphan (DXO)
- Dimemorfan
- Dimethyltryptamine (DMT)
- Ditolylguanidine (DTG)
- Donepezil
- Eliprodil
- Escitalopram
- Fabomotizole (afobazole)
- Fluoxetine
- Fluvoxamine
- Ifenprodil
- Igmesine (JO-1784)
- IPAB
- Ketamine
- L-687384
- MDMA (midomafetamine)
- Memantine
- Methamphetamine
- Methoxetamine
- Methylphenidate
- Nepinalone
- Neuropeptide Y
- Noscapine
- OPC-14523
- Opipramol
- Pentazocine
- Pentoxyverine (carbetapentane)
- PRE-084
- Pregnenolone
- Pregnenolone sulfate
- Pridopidine
- Racemethorphan (methorphan)
- Racemorphan (morphanol)
- UMB-23
- UMB-82
- Antagonists: 3-PPP
- AC-927
- BD-1008
- BD-1031
- BD-1047
- BD-1060
- BD-1063
- BD-1067
- BMY-14802 (BMS-181100)
- CM-156
- Dup-734
- E-5842
- E-52862 (S1RA)
- Haloperidol
- LR-132
- LR-172
- MS-377
- NE-100
- NPC-16377
- Panamesine (EMD-57455)
- PD-144418
- Pentazocine
- Progesterone
- Rimcazole (BW-234U)
- Sertraline
- SR-31742A
- Allosteric modulators: Phenytoin; Positive: Methylphenylpiracetam
- SOMCL-668
- Unknown/unsorted: 3-Methoxydextrallorphan
- 3-MeO-PCP
- 4C-T-2
- 4-IBP
- 4-IPBS
- 4-MeO-PCP
- 5-MeO-DALT
- 5-MeO-DiPT
- Amitriptyline
- Azidopamil
- Chlorpromazine
- Clemastine
- Clomipramine
- Clorgiline
- D-Deprenyl
- DiPTTooltip N,N-Diisopropyltryptamine
- DPTTooltip N,N-Dipropyltryptamine
- Ibogaine
- Imipramine
- KCR-12-83.1
- Nemonapride
- Noribogaine
- RHL-033
- RS-67,333
- RTI-55
- Saffron
- Safinamide
- Selegiline
- Spipethiane
- Trifluoperazine
- W-18
- YKP10A
- Agonists: 3-PPP
- Arketamine
- BD-1047
- BD1063
- Ditolylguanidine (DTG)
- DKR-1005
- DKR-1051
- Haloperidol
- Ifenprodil
- Ketamine
- MDMA (midomafetamine)
- Methamphetamine
- OPC-14523
- Opipramol
- PB-28
- Phencyclidine
- Siramesine (Lu 28-179)
- UKH-1114
- Unknown/unsorted: 3-Methoxydextrallorphan
- 3-MeO-PCE
- 4-MeO-PCP
- 5-MeO-DALT
- 5-MeO-DiPT
- Clemastine
- DiPTTooltip N,N-Diisopropyltryptamine
- DPTTooltip N,N-Dipropyltryptamine
- Ibogaine
- Nemonapride
- Nepinalone
- Noribogaine
- Pentazocine
- RS-67,333
- Safinamide
- TMATooltip 3,4,5-Trimethoxyamphetamine
- UMB-23
- UMB-82
- W-18
- Antagonists: AHD1
- AZ66
- Lamotrigine
- Naloxone
- SM-21
- UMB-100
- UMB-101
- UMB-103
- UMB-116
- YZ-011
- YZ-069
- YZ-185
- Allosteric modulators: SKF-83959
- Unknown/unsorted: 18-Methoxycoronaridine
- BMY-13980
- Butaclamol
- Caramiphen
- Carvotroline
- Chlorphenamine (chlorpheniramine)
- Chlorpromazine
- Cinnarizine
- Cinuperone
- Clocapramine
- Dezocine
- EMD-59983
- Hypericin (St. John's wort)
- Fluphenazine
- Gevotroline (WY-47384)
- Mepyramine (pyrilamine)
- Molindone
- Perphenazine
- Pimozide
- Proadifen
- Promethazine
- Propranolol
- Quinidine
- Remoxipride
- SL 82.0715
- SR-31747A
- Tiospirone (BMY-13859)
- Venlafaxine
See also: Receptor/signaling modulators
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e